Molecular Medicine Report Writing – Nursing Assignment Help

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Abstract. – Malignant gliomas are the most common type of primary malignancy of the central nervous system, with a poor prognosis. The therapeutic options for malignant gliomas are limited and far from satisfactory, and novel treatment strategies are urgently required to improve the outcome of the disease. Insulin-like growth factor (IGF)/IGF-1 receptor (IGF-1R) signaling pathway regulates cell proliferation, motility and survival. The dysregulation of this signaling pathway has been implicated in the development of malignant gliomas. In the present study, GSK1904529A, a small molecule inhibitor of IGF-1R, suppressed glioma cell viability, induced glioma cell apoptosis and inhibited glioma cell migration in vitro. In addition, GSK1904529A inhibited glioma tumor growth and induced tumor cell apoptosis in vivo. In conclusion, the results of the present study suggested GSK1904529A as a promising agent for the treatment of malignant glioma.

Introduction

Gliomas are the most common type of primary brain tumor in humans, accounting for >80% of all brain malignancies (1). Gliomas are classified into astrocytomas (Grade I?IV), oligodendrogliomas (Grade II and III),ependymomas (Grade I-III) and mixed oligo-astrocytomas (Grade II and III), according to the World Health Organization (1,2). Glioblastoma, also termed glioblastoma multiforme, is a Grade IV astrocytoma, which is the most aggressive form of glioma, and accounts for ~60-70% of all malignant gliomas worldwide (1,3). The prognosis for patients diagnosed with glioblastoma is particularly poor, with 1-year and 5-year survival rates at ~36% and 5%, respectively (1,4). Current treatments for malignant gliomas include maximal surgical resection whenever possible, radiotherapy and chemotherapy, however, no significant improvements in survival rates have been achieved (5) and there remains urgent requirement for the identification of novel molecular targets and therapies.

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